Acesulfame K. Ethoxyquin. Artificial smoke flavor.
The
 first, an artificial sweetener; the second, a preservative; and the 
third, a flavor enhancer, are just a few of the ingredients that Panera Bread wants to banish from its kitchens by the end of 2016.
In
 doing so, Panera would join the growing ranks of food companies and 
restaurants that have announced plans to eliminate a variety of 
artificial preservatives, flavors and colors, as well as different kinds
 of sweeteners and meat from animals raised with antibiotics, in 
response to consumer demands for transparency and simplicity in the 
foods they eat.
“We’re
 trying to draw a line in the sand in the industry so that consumers 
have an easy way to know what’s in the food they buy,” said Ron Shaich, 
chief executive of Panera.
In
 the last six months, at least a dozen food companies and restaurant 
businesses have announced plans to reformulate products to eliminate 
ingredients. “To me, this has gone way beyond anything that could even 
be remotely considered a fad and become a powerful trend,” said Carl 
Jorgensen, director for global consumer strategy focusing on wellness at
 Daymon Worldwide, a consulting firm.
Nestlé
 USA has said it will remove artificial flavorings and colors from its 
chocolate candy products, including brands like Butterfinger and Baby 
Ruth, as well as from Nesquik powdered drink mixes.
Hershey
 in December said it would work to replace high-fructose corn syrup in 
sweets like York peppermint patties and Almond Joy candy bars. Two 
months later, the company said it was moving to make all of its products
 from “ingredients that are simple and easy to understand.”
Kraft
 recently said it would replace the artificial colorings that give 
Macaroni and Cheese its orange hue with colors derived from spices like 
turmeric and paprika, and PepsiCo announced that it would use sucralose 
to sweeten Diet Pepsi instead of the artificial sweetener aspartame.
Last
 month, McDonald’s became the latest major restaurant chain to say it 
would no longer sell products made with chicken treated with human 
antibiotics. A few weeks later, Tyson Foods, a major meat company that 
is one of McDonald’s suppliers, said it would eliminate such antibiotics
 from its poultry and begin working to get them out of other meats as 
well.
Even
 Snackwell, which started its life as a brand with reduced fat, is 
undergoing a makeover aimed at getting rid of high-fructose corn syrup, 
hydrogenated oils and artificial colors and flavors. “In this day and 
age, the consumer who was satisfied with reduced fat or fat-free 20 
years ago is not satisfied with that any more,” said Vincent 
Fantegrossi, chief executive of the Back to Nature Foods Company, which 
is owned by Brynwood Partners, a private equity group.
Retooling
 an iconic brand is tricky. Companies must make sure that consumers 
cannot detect any change in taste, texture or quality, or all may be 
lost.
“That
 actually makes the challenge for companies like us that have well-known
 brands greater, compared to small companies that can simply make a 
product from scratch without these ingredients,” said Leslie Mohr, 
marketing manager for NestlĂ© USA’s confectionary business.
While
 most of the companies have been careful to say they are merely 
responding to consumer demands, not making a value judgment on such 
ingredients, they often face heavy criticism. Chipotle Mexican Grill’s 
announcement that it had eliminated genetically modified ingredients 
from the foods it makes — though, like Panera, not from the sodas it 
sells — evoked a torrent of outraged responses.
The Washington Post editorial board called Chipotle’s move a “gimmick” that was “hard to swallow,” while NPR’s popular food blog, The Salt,  accused
 the company of having a double standard for adopting sunflower oil, 
which it said was often treated with a pesticide known for weed 
resistance.
“This
 is a complicated issue, and I would suggest there is less here than 
meets the eye,” said L. Val Giddings, a senior fellow at the Information
 Technology and Innovation Foundation.
Mr.
 Giddings noted that although General Mills got a lot of publicity for 
eliminating genetically modified ingredients from original Cheerios, 
those were just a tiny part of the cereal’s ingredients. “I think what 
they were doing at least in part was testing the water to see if they 
could capitalize on it, and what they have found is pretty 
illuminating,” he said. “The move had no impact on sales.”
Mr.
 Shaich said Panera’s decision to come up with what it calls “The No No 
List” had more to do with protecting the sales it has. The list is based
 on research and standards developed by Johns Hopkins, the Environmental
 Working Group, the Natural Resources Defense Council and various 
European governments.
“I’m
 not a scientist and I’m not wading into the debate over whether any of 
these things cause cancer or are otherwise bad for you,” he said. “I 
just think this is where the consumer’s head is right now.”
Panera
 uses more than 450 ingredients to prepare its foods. The company had to
 work with both its suppliers and their suppliers, who themselves were 
not always sure whether their products contained the ingredients Panera 
has decided to eliminate.
“These
 ingredients have been added over time to improve efficiency and 
consistency and as preservatives as supply chains have gotten longer and
 longer,” said Sara Burnett, senior quality assurance manager at Panera.
Solutions
 are not always perfect. Panera is rejecting titanium dioxide, a 
whitener commonly used in products like ice cream and icings, from its 
mozzarella, yet cheese browns as it ages. “We don’t know how customers 
will react,” Ms. Burnett said.
Salad
 dressing proved the menu item most difficult to reformulate, she said, 
in part because different oils impart specific viscosity and taste. For 
Greek salad dressing, Panera had to take apart the spice mix it used and
 go back to the basics — lemon juice, garlic, oregano and rosemary.
“We learned we don’t have to have these things on the list,” Ms. Burnett said, “so why have them?”
         Correction: May 6, 2015  
An article on Tuesday about Panera Bread’s decision to remove many artificial colors, flavors and preservatives from its ingredients erroneously included one cereal among those from which General Mills has eliminated genetically modified ingredients. Grape-Nuts is made by Post, not General Mills, and therefore is not one of the cereals affected.
    
An article on Tuesday about Panera Bread’s decision to remove many artificial colors, flavors and preservatives from its ingredients erroneously included one cereal among those from which General Mills has eliminated genetically modified ingredients. Grape-Nuts is made by Post, not General Mills, and therefore is not one of the cereals affected.

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