This particular drug revolves around a compound called larazotide acetate, a tight junction regulator. The compound, at least in theory works by temporarily closing off the junctions in the bowel that – in a quote-on-quote “normal” digestive system – are normally closed anyway. These junctions are supposed to only open to shed dead blood cells, but remain open more frequently in cases of celiac disease. In other words, the drug would plug up the leaks in a leaky gut, and if taken before a meal could reduce the inflammation caused by gluten.
The company has developed a questionnaire to pre-screen people for participation in their eventual trials. If you think you might like to participate in the trials, you can learn more via the website, www.celiactrial.com. Quickly though, in order to be eligible to even be considered for participation you would need to meet the following criteria:
- between the ages of 18 and 75
- diagnosed with celiac disease via either biopsy or capsule endoscopy
- attempting a gluten-free diet for at least 12 months
What do you think? Would you participate in a drug trial (knowing that potentially, you could be assigned to a control group that winds up ingesting gluten)?
-Triumph Dining
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