MS and Celiac Disease

Multiple Sclerosis Patients Present With High Incidence of Celiac Disease
by Dr. Sania Siddiqui, MedIndia.net
Celiac disease (CD) is a common systemic disorder related to gluten intolerance and is often associated with different autoimmune and neurological diseases.
The study’s lead author Dr. Luis Rodrigo of University Hospital, Central Asturias, Spain and colleagues ana-lyzed the prevalence of serological, genetic, and histological disease markers in 72 multiple sclerosis patients and 126 of their first-degree relatives. Then the results were compared with data from 123 healthy control subjects. The results depicted seven MS patients (10%) with positive screens for tissue IgA-anti-transglutaminase-2 antibodies, compared with three positive screens for healthy controls (2.4%). The team realized there is little difference in HLA-DQ2 markers between MS patients (29%) and controls (26%) (NS). They found eight MS patients (11.1%) with mild or moderate villous atrophy (Marsh III type) in duodenal biopsies. Results also exhibited celiac disease in 26 of 126 first-degree relatives (32%).
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